Media milling, high pressure homogenization in water, high pressure homogenization in nonaqueous media and combination of precipitation and high pressure homogenization are the various method of preparation of nanosuspension.[7,8] Nanosuspension approaches have been employed for various drugs including tarazepide, atovaquone, amphotericin B, etc.
· Wet media milling has been regarded as a topdown approach for the industrial production of nanosuspensions and benefits from high efficiency, low cost, and free of organic residue (Ghosh et al. 2012; Li et al. 2016). Based on these superiorities, wet media milling provides a novel and easy method to produce poorly soluble fungicides.